2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141165
    TCO-NHS ester 1191901-33-3
    TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-NHS ester
  • HY-117009
    Bis-PEG9-NHS ester 1008402-79-6 98.0%
    Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG9-NHS ester
  • HY-W096093
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 1035373-85-3 99.90%
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride
  • HY-140212
    Azido-PEG1-amine 464190-91-8 98.0%
    Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-amine
  • HY-W042255
    tert-Butyl 3-bromopropanoate 55666-43-8 99.90%
    tert-Butyl 3-bromopropanoate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 3-bromopropanoate
  • HY-W001056
    3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid 83249-10-9 99.72%
    3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
    3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid
  • HY-W010642
    Pent-4-yn-1-ol 5390-04-5 99.59%
    Pent-4-yn-1-ol is a PROTAC linker. Pent-4-yn-1-ol can be used to synthesize PROTAC molecules (e.g. RD-23 (HY-168867)).
    Pent-4-yn-1-ol
  • HY-130291
    Biotin-PEG3-NHS ester 1253286-56-4 99.35%
    Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG3-NHS ester
  • HY-42490
    N3-PEG3-CH2CH2COOH 1056024-94-2 98.0%
    N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2COOH
  • HY-W002926
    tert-Butyl N-[4-(aminomethyl)phenyl]carbamate 220298-96-4 98.94%
    tert-Butyl N-[4-(aminomethyl)phenyl]carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl N-[4-(aminomethyl)phenyl]carbamate
  • HY-69260
    tert-Butyl 4-formylpiperidine-1-carboxylate 137076-22-3 99.54%
    tert-Butyl 4-formylpiperidine-1-carboxylate is a PROTAC linker and can be used in the synthesis of PROTAC BRM/BRG1 degrader-3 (HY-168251).
    tert-Butyl 4-formylpiperidine-1-carboxylate
  • HY-140208
    2,2-Oxybis(ethylamine) 2752-17-2 99.96%
    22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2,2-Oxybis(ethylamine)
  • HY-Y0925
    5-Hexynoic acid 53293-00-8
    5-Hexynoic acid (Hex-5-ynoic acid) is an alkynoic acid. 5-Hexynoic acid serves as a drug intermediate for the synthesis of 3-alkoxy-2-cyclohexenone.
    5-Hexynoic acid
  • HY-140453
    Azido-PEG6-acid 361189-66-4 99.91%
    Azido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-acid
  • HY-33462
    6-Amino-1-hexanethiol hydrochloride 31098-40-5 98.0%
    6-Amino-1-hexanethiol hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs.
    6-Amino-1-hexanethiol hydrochloride
  • HY-130503
    N-Boc-PEG1-bromide 164332-88-1
    N-Boc-PEG1-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG1-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG1-bromide
  • HY-141336
    α-Lipoic acid-NHS 40846-94-4 98.0%
    α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    α-Lipoic acid-NHS
  • HY-W012241
    Dodecanedioic acid 693-23-2 98.0%
    Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic acid
  • HY-126889
    Bis-PEG5-NHS ester 756526-03-1 99.83%
    Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG5-NHS ester
  • HY-140273
    DBCO-PEG8-NHS ester 2553412-88-5 98.34%
    DBCO-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG8-NHS ester
PROTAC Linkers Isoform Comparison

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